Biopharmaceutical Storage & Handling: pH & Acidity

Image of pH Testing Kit

Introduction pH is a measure of Hydrogen ion concentration and can also be described as ‘A measure of how acidic a solution is‘. Low pH (0-3) environments are most acidic while high pH (11-14) environments are least acidic and described as alkaline or basic. As mentioned previously, protein structure is dependent on a combination of chemical bonds and electrostatic (Stationary … Read More


Biopharmaceutical Storage & Handling: Solutes & Solvents

As noted in earlier posts such as ‘Biopharmaceutical Protein Structure – Part 1‘, the elaborate 3-dimensional structure of proteins is maintained by a complex interplay of chemical bonds and electrostatic interactions. These electrostatic interactions primarily involve the charged side-groups of the protein’s constituent amino acids. As seen in Figure 1 below, the ‘R‘ groups which represent clusters of atoms unique to each … Read More


What is the ‘Cold Chain’?

The pervasiveness of biopharmaceuticals (biologics) in the 21st century pharmaceutical landscape, means that the presence of ‘heat-labile’ pharmaceuticals even in the ‘corner-store’ pharmacy is almost guaranteed. It is therefore essential that every pharmacist and all dispensary staff have some basic knowledge on how to store, handle and transport Cold Chain Products (CCPs).  Cold Chain Products (CCPs) are those requiring storage under refrigerated conditions of 2-8°C. … Read More


Biopharmaceutical Stability, Storage & Handling: An Introduction

Block of blue vials

Having previously discussed the fundamentals of biotechnology, its impact on the production of medicines and the structure of these protein-based medicines, we now move on to some of the practical aspects of managing therapeutic proteins. In this post we begin our exploration of the storage and handling of biopharmaceuticals. As noted before, because proteins represent the overwhelming majority of products from the pharmaceutical biotechnology sector, … Read More


Biopharmaceutical Protein Structure – Part 2

Introduction Our last post entitled, ‘Biopharmaceutical Protein Structure – Part 1‘, looked briefly at the interplay of different chemical bonds common to proteins and their respective contributions to the maintenance of protein structure. We will now apply those principles to the current discussion and explore in greater detail the four levels of protein structure with particular emphasis on the structural complexity of proteins. The Structural Complexity of … Read More